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Project Details
  • Title: Bone Morphogenetic Protein in the Treatment of Glial Tumors
  • Date Proposed: 04/23/2009
  • Amount Requested: $10,000.00
  • Amount we Paid: $10,000.00
  • Paid Date: 05/11/2009
  • Stauts: Approved - Waiting For Funding
  • Research name: Maryam Rahman MD
  • Hospital: University of Florida, Department of Neurosurgery
  • Grey Ribbon Crusade Participants:
    • Musella Foundation For Brain Tumor Research & Information, Inc
    • Just One More Day for Love, Hope & a Cure
    • Oligo Fund of Musella Foundation
    • Gunner's Magic Train Pediatric Cancer Foundation
  • Simple Description: Transformed precursor cells with stem cell qualities may be responsible for the development of human solid tissue tumors including glial tumors. These cells are thought to be resistant to conventional therapy for human glial tumors. Conventional therapy often targets the entire tumor population in a non-specific fashion and spares the tumor stem cells because of their unique properties. The tumor stem cells can be targeted with differentiation therapy that would cause them to lose their stem cell qualities and therefore more sensitive to conventional therapy. We are studying bone morphogenetic protein (BMP) 4 as differentiation therapy for human glial tumors. We will be analyzing the effects of BMP 4 on cell proliferation in cell culture and expression of proliferation proteins. These results will be used to design an animal study for the efficacy of BMP 4 on human glial tumors. We will be testing the following tumor types: glioblastoma multiforme, oligodendroglioma, anaplastic astrocytoma, low grade astrocytoma, juvenile pilocytic astrocytoma, ependymoma and pilocytic xanthochromic astrocytoma
  • Interim report: Project progressing nicely!
  • Final Report: Completed and presented at SNO Annual Conference in New Orleans, 2009
  • Published report: http://virtualtrials.com/pdf/Rahman09b.pdf